Non-invasive lesions that remains within the breast lobule and do not grow beyond it. It is not a cancer. “In situ” means that a lesion does not pass the basement membrane which is why this lesion cannot spread to the lymph nodes or other organs. LCIS is thus, non life-threatening. Pleomorphic LCIS acts more like a high risk lesion (similar to DCIS), that in some cases may develop into an invasive cancer by continuing to grow beyond the basement membrane and this is why the recommendation is to remove it, to prevent this from happening.
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